Visualizing how changing a parameter affects a result can be useful for honing one’s intuition. Below are simple programs that plot an observable and allow the user to change the input parameters using GUI sliders. Executables (Mac OS X) for the helix-coil zipper model, the Shottky 2-state model and the Gibbs-Helmholz equation are provided and discussed below.
Helix-coil zipper model
This is a simple demonstration of the Zimm-Bragg zipper model that allows you to see the effect of varying the “s”, “sigma” and number of residues. For more information consult Cantor and Shimmel Vol 3 Chapter 20.
2-state Shottky model